INCINTA Fertility Center (USA) Celebrates Success: 42-Year-Old Patient Breaks Through After Two ‘Empty Follicle’ Cycles to Achieve a 5AA Embryo

Age may present challenges on the fertility journey—but it never defines the outcome. At 42, Ms. S endured two unsuccessful IVF cycles with no mature oocytes retrieved; yet, empowered by science and a highly personalized protocol at INCINTA, her third cycle yielded 15 mature oocytes and a precious, PGT-screened 5AA-grade embryo.

On the fertility journey, age may present challenges—but it never defines the outcome.

[图片:https://cdn.yun.sooce.cn/6/59417/jpg/1748418583125adaa741a10aa3cb9f133c7a9c32d58f0.jpg?version=0][A patient visiting INCINTA’s Beverly Hills center]

At 42, Ms. S endured two previous egg retrievals yielding no mature oocytes—yet scientific insight and a fully individualized treatment plan brought her breakthrough: with INCINTA’s support, her third cycle not only produced 15 mature oocytes but also resulted in a high-quality, PGT-screened 5AA-grade embryo!

Two Stimulations—All Oocytes Immature

Ms. S’s first two ovarian stimulations were performed at a clinic in Country A—with disappointing outcomes.

First Cycle: January 2023

17 oocytes retrieved—all at the germinal vesicle (GV) stage (“empty follicles”). The stimulation protocol was reduced mid-cycle; total duration: 8 days. Outcome fell short of expectations.

Second Cycle: February 2024

16 oocytes retrieved—again, all GV-stage. No protocol adjustments were made; stimulation lasted 8 days—yet another unsatisfactory result.

After two failed attempts, Ms. S realized that physician expertise, truly personalized protocols, and laboratory technical excellence are pivotal to success.

Meeting INCINTA—Reigniting Hope for Parenthood

While touring INCINTA’s Beverly Hills center in Los Angeles and observing its newly introduced medical robotics system, Ms. S met Dr. Lin.

After consulting numerous physician friends, she learned that Dr. Lin is among the top reproductive endocrinologists in Los Angeles—with over 25 years of clinical experience specializing in reproductive endocrinology and infertility. He excels in designing customized protocols for advanced maternal age patients, and his affiliated INCINTA Fertility Center boasts an exceptionally strong embryology team.

Following thorough due diligence, Ms. S chose INCINTA to begin her third IVF journey.

Precision Protocol Adjustment—Yielding a 5AA-Grade Embryo

Given the rarity and complexity of Ms. S’s case—two consecutive GV-only retrievals—numerous physiological and pharmacological factors required careful evaluation. Dr. Lin therefore prioritized her case, collaborating closely with Chief Embryologist Dr. Xie to analyze prior data. They identified poor ovarian responsiveness to conventional stimulation regimens and impaired oocyte maturation.

Accordingly, Dr. Lin designed a fully individualized protocol:

• Increased starting dose: Gonal-F 300 IU + Menopur 150 IU;

• Dynamic medication adjustment: After 3 days, slow estradiol rise prompted escalation of Menopur to 225 IU;

• Extended stimulation duration: 12-day protocol—providing ample time for oocyte maturation;

• Dual laboratory safeguards: Embryology team prepared an IVM (in vitro maturation) contingency plan.

[图片:https://cdn.yun.sooce.cn/6/59417/jpg/17484185832129b6741094a9e0c6e176e3a8f5482c827.jpg?version=1748418585][Dr. Lin and the INCINTA embryology team reviewing Ms. S’s case]

This time, results far exceeded expectations:

◾ 26 oocytes retrieved—more than double the prior count;

◾ 15 reached MII maturity;

◾ All 15 fertilized successfully—100% fertilization rate;

◾ 7 blastocysts developed, including one top-tier 5AA embryo confirmed via PGT screening.

Overwhelmed with emotion, Ms. S exclaimed: “It wasn’t my eggs—it was the protocol that needed refinement!”

Racing Against Time—Launching a New Cycle

Although one high-quality embryo has already been secured, 42-year-old Ms. S understands that ovarian function declines progressively—and timing is critical.

She has now decided to initiate her next IVF cycle at INCINTA, aiming to accumulate additional healthy, high-grade embryos to maximize her chances of building the family she dreams of.

Success is never accidental: personalized protocols, physician expertise, and laboratory technical excellence are inseparable pillars of achievement. INCINTA—powered by World Fertility Industry Alliance (WFA) standards—commits to delivering professional, compassionate care to help more families realize their dreams of parenthood.

This article is a public-information summary published by WFA. It is intended for industry, media and the general public, and does not constitute medical or investment advice.